Master Student für 1 Jahr (Geringfügige Anstellung) ovarian cancer in Wien bei Medizinische Universität Wien

Master Student für 1 Jahr (Geringfügige Anstellung) ovarian cancer

Medizinische Universität Wien, Wien

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Master Thesis: Molecular Biology
Subject area: Molecular Biology of Ovarian Cancer
Location: Ebene 5Q, AKH
Translational Gynecology Group, Department of Obstetrics and Gynecology, Medical University of Vienna
Duration: 1 year, start on 1.9.2020
Payment: Geringfügige Anstellung (ca. 460€/Monat)
Contact: Prof. Dan Cacsire Castillo-Tong
Telephone: +43-1-40400-78330

Mucinous ovarian cancer is a rare epithelial cancer and is not well investigated. Patients have poor prognosis because there is no specific treatment. Therefore there is urgent need to understand the molecular background of the mucinous cancer and to define therapeutic targets.

• to study molecular mechanisms underlying mucinous ovarian cancer
• to define genes/pathways as new therapeutic targets
• to evaluate targetable genes

Experimental techniques include genetics, gene expression and protein expression analysis of tumor cells (cell culture, RT-qPCR, Western blotting, cloning, fragment analysis, sequencing), IHC, IF, apoptosis assay, viability/survival assays, senescence assays.

Good basic knowledge of molecular biology, strong analytic capacity and commitment, as well as interest in science.

Selected relevant publications:

• Kreuzinger C, Decken IV, Wolf A, Gamperl M, Koller J, Karacs J, Pfaffinger S, Bartl T, Reinthaller A, Grimm C, Singer CF, Braicu EI, Cunnea P, Gourley C, Smeets D, Boeckx B, Lambrechts D, Perco P, Horvat R, Berns EMJJ, Castillo-Tong DC. Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer. Cancer Lett. 10;459:1-12, 2019. doi: 10.1016/j.canlet.2019.05.032.

• Kreuzinger C, Geroldinger A, Smeets D, Braicu EI, Sehouli J, Koller J, Wolf A, Darb-Esfahani S, Jöhrens K, Vergote I, Vanderstichele A, Boeckx B, Lambrechts D, Gabra H, Wisman GBA, Trillsch F, Heinze G, Horvat R, Polterauer S, Berns EMJJ, Theillet CG, Cacsire Castillo-Tong D. A complex network of tumor microenvironment in human high grade serous ovarian cancer. Clin Cancer Res. 2017 Oct 2. pii: clincanres.1159.2017. doi: 10.1158/1078-0432.CCR-17-1159. [Epub ahead of print]

• Kreuzinger C, Gamperl M, Wolf A, Heinze G, Geroldinger A, Lambrechts D, Boeckx B, Smeets D, Horvat R, Aust S, Hamilton G, Zeillinger R, Cacsire Castillo-Tong D. Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer. Cancer Lett. 362:218-28, 2015. doi: 10.1016/j.canlet.2015.03.040.

nach Besprechung h/Woche
Ebene 5Q, Währinger Gürtel 18-20, AKH 1090 Wien
ca. 460€ / Monat EUR pro Stunde
Medizinische Universität Wien
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