Master Thesis - Machine Learning - BioLayer Interferometry - ELISA (f/m/d) in Orth an der Donau bei Takeda
Master- / Diplomarbeit, Vollzeit bei Takeda

Master Thesis - Machine Learning - BioLayer Interferometry - ELISA (f/m/d)

Takeda, Bezirk Gänserndorf

Takeda’s Gene Therapy Analytics team is looking for talented and highly motivated candidates for pursuing a Master of Science program, in which the student will develop a quantification method of virus capsids based on Bio-Layer Interferometry (BLI) technology, which should deliver comparable results to the enzyme-linked immunosorbent assay (ELISA) method. To date, different orthogonal methods were developed for the quantification of recombinant Adeno-Associated Virus (rAAV). Among others, ELISA is one of the most popular analytical tools used in the pharmaceutical industry, as it offers large versatility to detect specific serotypes and is a standard equipment in most of labs. Nevertheless, new technologies such as BLI offers a more sophisticated technology able to bring additional information (binding capacity, full/empty ratio of Capsids, faster quantification compared to ELISA, etc.)

Objectives

The master thesis includes the Capsid quantification with BLI compared to ELISA, the execution of experiments under supervision, as well as data analysis and evaluation of results. The benefit of this master thesis is a new and faster technology for using immunoassays in process development.

  • Independent planning and execution of experiments
  • Data evaluation using selected mathematical software
  • Preparation and presentation of results in internal meetings
  • Evaluation of full/empty ratios of different rAAV capsid serotypes with machine learning
  • Evaluation of binding capacity of selected binding components to the capsids
  • Collaboration with internal and cross-functional teams and academic researchers

Our requirements

  • Bachelor’s degree in Biochemistry, Analytical Chemistry, preferred
  • Interest in programming and basic statistics
  • Ability to clearly communicate ideas and knowledge
  • Willingness to work hands-on at wetlab and with teams
  • Excellent command of German and English
  • Position is limited - 6 month

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Takeda encourages and supports its employees by trainings, job rotations and mentoring. A balanced work – life ratio (recognition for work and family, company kindergarten in Vienna) and numerous benefits (free Shuttlebus Vienna/Orth, cafeteria, etc.) complete our profile as a top employer. For more insights into Takeda click here.

We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Gender, age, skin color, background or sexual orientation play no role in this as we actively promote diversity. We equally address people with disabilities. In the course of a recruitment process which is as free of barriers as possible, we encourage you to mention all relevant information in this context in your application.

Motivated employees must be remunerated appropriately. The minimum salary for this important and responsible position is € 1.565,90 gross per month (full time, collective wage agreement for the chemical industry).

Jobart:
Master- / Diplomarbeit, Vollzeit
Arbeitsbeginn:
as of now
Wochenstunden:
38.5 h/week
Standort:
Orth an der Donau, Österreich
Gehalt:
1.565,90 € gross per month
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